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Targeting the IL-12/IL-23 axis: An alternative approach to removing tumor induced immune suppression
Combination immune checkpoint blockade has demonstrated significant clinical responses in cancers infiltrated by T cells. Many tumors contain high proportions of myeloid cells and these can secrete immunosuppressive cytokines like IL-23. Our data suggest the clinical potential of using anti-CD40 (pu...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Landes Bioscience
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108456/ https://www.ncbi.nlm.nih.gov/pubmed/25083324 http://dx.doi.org/10.4161/onci.28964 |