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Hormesis in cancer immunology: Does the quantity of an immune reactant matter?

We recently reported that tumor-directed antibodies could either stimulate, or inhibit, tumor progression, dependent upon the dosage used. The narrow range over which this immune response curve (IRC) occurs is surprising. Here we discuss features of the IRC, the mechanisms identified so far, and the...

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Detalles Bibliográficos
Autores principales: Pearce, Oliver MT, Läubli, Heinz, Bui, Jack, Varki, Ajit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108457/
https://www.ncbi.nlm.nih.gov/pubmed/25083340
http://dx.doi.org/10.4161/onci.29312