A novel preclinical murine model of immune-mediated metastatic dormancy

The mechanisms underlying cancer dormancy are poorly understood. We have developed a preclinical murine model in which immunosurveillance restrains spontaneous metastases in permanent dormancy. The model faithfully recapitulates human metastatic dormancy and may be useful to decipher the immune mech...

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Detalles Bibliográficos
Autores principales: Romero, Irene, Garrido, Federico, Garcia-Lora, Angel M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108459/
https://www.ncbi.nlm.nih.gov/pubmed/25083338
http://dx.doi.org/10.4161/onci.29258
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author Romero, Irene
Garrido, Federico
Garcia-Lora, Angel M
author_facet Romero, Irene
Garrido, Federico
Garcia-Lora, Angel M
author_sort Romero, Irene
collection PubMed
description The mechanisms underlying cancer dormancy are poorly understood. We have developed a preclinical murine model in which immunosurveillance restrains spontaneous metastases in permanent dormancy. The model faithfully recapitulates human metastatic dormancy and may be useful to decipher the immune mechanisms constraining disease progression, thereby facilitating the development of novel immunotherapeutic approaches to control metastatic disease.
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spelling pubmed-41084592014-07-31 A novel preclinical murine model of immune-mediated metastatic dormancy Romero, Irene Garrido, Federico Garcia-Lora, Angel M Oncoimmunology Author's View The mechanisms underlying cancer dormancy are poorly understood. We have developed a preclinical murine model in which immunosurveillance restrains spontaneous metastases in permanent dormancy. The model faithfully recapitulates human metastatic dormancy and may be useful to decipher the immune mechanisms constraining disease progression, thereby facilitating the development of novel immunotherapeutic approaches to control metastatic disease. Landes Bioscience 2014-06-25 /pmc/articles/PMC4108459/ /pubmed/25083338 http://dx.doi.org/10.4161/onci.29258 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Romero, Irene
Garrido, Federico
Garcia-Lora, Angel M
A novel preclinical murine model of immune-mediated metastatic dormancy
title A novel preclinical murine model of immune-mediated metastatic dormancy
title_full A novel preclinical murine model of immune-mediated metastatic dormancy
title_fullStr A novel preclinical murine model of immune-mediated metastatic dormancy
title_full_unstemmed A novel preclinical murine model of immune-mediated metastatic dormancy
title_short A novel preclinical murine model of immune-mediated metastatic dormancy
title_sort novel preclinical murine model of immune-mediated metastatic dormancy
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108459/
https://www.ncbi.nlm.nih.gov/pubmed/25083338
http://dx.doi.org/10.4161/onci.29258
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