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Pancreatic cancer: Hurdles in the engineering of CAR-based immunotherapies

Pancreatic cancer remains largely an incurable disease necessitating the development of novel therapeutic approaches. Adoptive immunotherapy using chimeric antigen receptor (CAR)-transduced T cells represents an alternative treatment with curative potential. We present an overview of the engineering...

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Detalles Bibliográficos
Autores principales: Abate-Daga, Daniel, Rosenberg, Steven A, Morgan, Richard A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108460/
https://www.ncbi.nlm.nih.gov/pubmed/25083334
http://dx.doi.org/10.4161/onci.29194