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Antibody-based depletion of Foxp3+ T cells potentiates antitumor immune memory stimulated by mTOR inhibition

Inhibition of mTOR signaling enhances antitumor memory T lymphocytes while increasing the frequency of immunosuppressive regulatory T cells (Tregs). We report here a strategy to further improve immunologic memory by controlling CD4(+) T cells with CD4-depleting monoclonal antibody therapy thereby im...

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Detalles Bibliográficos
Autor principal: Kim, Hyung L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108462/
https://www.ncbi.nlm.nih.gov/pubmed/25083329
http://dx.doi.org/10.4161/onci.29081