‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer

Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40(-) Tregs in non-cirrhotic tissues in contra...

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Autores principales: Piconese, Silvia, Timperi, Eleonora, Barnaba, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108463/
https://www.ncbi.nlm.nih.gov/pubmed/25083337
http://dx.doi.org/10.4161/onci.29257
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author Piconese, Silvia
Timperi, Eleonora
Barnaba, Vincenzo
author_facet Piconese, Silvia
Timperi, Eleonora
Barnaba, Vincenzo
author_sort Piconese, Silvia
collection PubMed
description Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40(-) Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40(+) Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C.
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spelling pubmed-41084632014-07-31 ‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer Piconese, Silvia Timperi, Eleonora Barnaba, Vincenzo Oncoimmunology Author's View Human regulatory T cells (Tregs) comprise an array of distinct subsets displaying diverse functions in response to microenvironmental signals. Here, we review our recent findings demonstrating the preferential accumulation of uncommitted, Th1-like and OX40(-) Tregs in non-cirrhotic tissues in contrast to the presence of committed, Th1-suppressing and OX40(+) Tregs in cirrhotic and tumor contexts in human liver affected by chronic hepatitis C. Landes Bioscience 2014-06-17 /pmc/articles/PMC4108463/ /pubmed/25083337 http://dx.doi.org/10.4161/onci.29257 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Piconese, Silvia
Timperi, Eleonora
Barnaba, Vincenzo
‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
title ‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
title_full ‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
title_fullStr ‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
title_full_unstemmed ‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
title_short ‘Hardcore’ OX40(+) immunosuppressive regulatory T cells in hepatic cirrhosis and cancer
title_sort ‘hardcore’ ox40(+) immunosuppressive regulatory t cells in hepatic cirrhosis and cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108463/
https://www.ncbi.nlm.nih.gov/pubmed/25083337
http://dx.doi.org/10.4161/onci.29257
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