Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes

Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of...

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Detalles Bibliográficos
Autores principales: Robert, Lidia, Harview, Christina, Emerson, Ryan, Wang, Xiaoyan, Mok, Stephen, Homet, Blanca, Comin-Anduix, Begonya, Koya, Richard C, Robins, Harlan, Tumeh, Paul C, Ribas, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108466/
https://www.ncbi.nlm.nih.gov/pubmed/25083336
http://dx.doi.org/10.4161/onci.29244

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108466/
https://www.ncbi.nlm.nih.gov/pubmed/25083336
http://dx.doi.org/10.4161/onci.29244

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