Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes

Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of...

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Autores principales: Robert, Lidia, Harview, Christina, Emerson, Ryan, Wang, Xiaoyan, Mok, Stephen, Homet, Blanca, Comin-Anduix, Begonya, Koya, Richard C, Robins, Harlan, Tumeh, Paul C, Ribas, Antoni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108466/
https://www.ncbi.nlm.nih.gov/pubmed/25083336
http://dx.doi.org/10.4161/onci.29244
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author Robert, Lidia
Harview, Christina
Emerson, Ryan
Wang, Xiaoyan
Mok, Stephen
Homet, Blanca
Comin-Anduix, Begonya
Koya, Richard C
Robins, Harlan
Tumeh, Paul C
Ribas, Antoni
author_facet Robert, Lidia
Harview, Christina
Emerson, Ryan
Wang, Xiaoyan
Mok, Stephen
Homet, Blanca
Comin-Anduix, Begonya
Koya, Richard C
Robins, Harlan
Tumeh, Paul C
Ribas, Antoni
author_sort Robert, Lidia
collection PubMed
description Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of the T cell repertoire matches the immunotoxicity profile of the therapy.
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spelling pubmed-41084662014-07-31 Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes Robert, Lidia Harview, Christina Emerson, Ryan Wang, Xiaoyan Mok, Stephen Homet, Blanca Comin-Anduix, Begonya Koya, Richard C Robins, Harlan Tumeh, Paul C Ribas, Antoni Oncoimmunology Author's View Targeting immune inhibitory receptors has brought excitement, innovation and hope to cancer patients. Our recent work revealed the immunological effects of blocking the CTLA4 and PD-1 immune checkpoints on T cell receptor usage among peripheral blood cells, and further uncovers how the expansion of the T cell repertoire matches the immunotoxicity profile of the therapy. Landes Bioscience 2014-06-25 /pmc/articles/PMC4108466/ /pubmed/25083336 http://dx.doi.org/10.4161/onci.29244 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Robert, Lidia
Harview, Christina
Emerson, Ryan
Wang, Xiaoyan
Mok, Stephen
Homet, Blanca
Comin-Anduix, Begonya
Koya, Richard C
Robins, Harlan
Tumeh, Paul C
Ribas, Antoni
Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
title Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
title_full Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
title_fullStr Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
title_full_unstemmed Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
title_short Distinct immunological mechanisms of CTLA-4 and PD-1 blockade revealed by analyzing TCR usage in blood lymphocytes
title_sort distinct immunological mechanisms of ctla-4 and pd-1 blockade revealed by analyzing tcr usage in blood lymphocytes
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108466/
https://www.ncbi.nlm.nih.gov/pubmed/25083336
http://dx.doi.org/10.4161/onci.29244
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