The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA Repair

BRCA1 is a phosphoprotein involved in many biological processes, including transcription, ubiquitination, checkpoint control, homologous recombination, and DNA repair. We have demonstrated that protein phosphatase 1α (PP1α) interacts with BRCA1 via a PP1-binding motif (898)KVTF(901), and can dephosp...

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Detalles Bibliográficos
Autores principales: Chen, Bert Yu-Hung, Huang, Cheng-Hsiang, Lin, Ying-Hsi, Huang, Ching-Chun, Deng, Chu-Xia, Hsu, Lih-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108927/
https://www.ncbi.nlm.nih.gov/pubmed/25056273
http://dx.doi.org/10.1038/srep05812

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4108927/
https://www.ncbi.nlm.nih.gov/pubmed/25056273
http://dx.doi.org/10.1038/srep05812

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