Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia

BACKGROUND: Rho kinase over-activation is associated with nitric oxide (NO) reduction and atherosclerosis. Metformin is favorable for endothelial function improvement and cardiovascular outcomes. Whether cardio-protective effect of metformin is associated with Rho kinase activity is unknown. METHODS...

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Detalles Bibliográficos
Autores principales: Liu, Yan, Huang, Congwu, Ceng, Chuan, Zhan, Haiyong, Zheng, Dongdan, Han, Weixing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109376/
https://www.ncbi.nlm.nih.gov/pubmed/25028180
http://dx.doi.org/10.1186/1476-511X-13-115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109376/
https://www.ncbi.nlm.nih.gov/pubmed/25028180
http://dx.doi.org/10.1186/1476-511X-13-115

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