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Metformin enhances nitric oxide production and diminishes Rho kinase activity in rats with hyperlipidemia

BACKGROUND: Rho kinase over-activation is associated with nitric oxide (NO) reduction and atherosclerosis. Metformin is favorable for endothelial function improvement and cardiovascular outcomes. Whether cardio-protective effect of metformin is associated with Rho kinase activity is unknown. METHODS...

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Detalles Bibliográficos
Autores principales:	Liu, Yan, Huang, Congwu, Ceng, Chuan, Zhan, Haiyong, Zheng, Dongdan, Han, Weixing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109376/ https://www.ncbi.nlm.nih.gov/pubmed/25028180 http://dx.doi.org/10.1186/1476-511X-13-115

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