The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

Activity-dependent neurite outgrowth is a highly complex, regulated process with important implications for neuronal circuit remodeling in development as well as in seizure-induced sprouting in epilepsy. Recent work has linked outgrowth to collapsin response mediator protein 2 (CRMP2), an intracellu...

Descripción completa

Detalles Bibliográficos
Autores principales: Wilson, Sarah M., Moutal, Aubin, Melemedjian, Ohannes K., Wang, Yuying, Ju, Weina, François-Moutal, Liberty, Khanna, May, Khanna, Rajesh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109617/
https://www.ncbi.nlm.nih.gov/pubmed/25104922
http://dx.doi.org/10.3389/fncel.2014.00196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109617/
https://www.ncbi.nlm.nih.gov/pubmed/25104922
http://dx.doi.org/10.3389/fncel.2014.00196

Ejemplares similares