Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation

ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate. Although an association between elevated levels of ACSL4 and hepatosteatosis has been reported, the function of ACSL4 in hepatic FA metabolism and the regulation...

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Detalles Bibliográficos
Autores principales: Kan, Chin Fung Kelvin, Singh, Amar Bahadur, Stafforini, Diana M., Azhar, Salman, Liu, Jingwen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Biochemistry and Molecular Biology 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109760/
https://www.ncbi.nlm.nih.gov/pubmed/24879802
http://dx.doi.org/10.1194/jlr.M045971

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109760/
https://www.ncbi.nlm.nih.gov/pubmed/24879802
http://dx.doi.org/10.1194/jlr.M045971

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