Identification and characterization of a mirror-image oligonucleotide that binds and neutralizes sphingosine 1-phosphate, a central mediator of angiogenesis

The sphingolipid S1P (sphingosine 1-phosphate) is known to be involved in a number of pathophysiological conditions such as cancer, autoimmune diseases and fibrosis. It acts extracellularly through a set of five G-protein-coupled receptors, but its intracellular actions are also well documented. Emp...

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Detalles Bibliográficos
Autores principales: Purschke, Werner G., Hoehlig, Kai, Buchner, Klaus, Zboralski, Dirk, Schwoebel, Frank, Vater, Axel, Klussmann, Sven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109837/
https://www.ncbi.nlm.nih.gov/pubmed/24832383
http://dx.doi.org/10.1042/BJ20131422

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109837/
https://www.ncbi.nlm.nih.gov/pubmed/24832383
http://dx.doi.org/10.1042/BJ20131422

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