Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor

The epidermal growth factor receptor (EGFR) plays a key role in regulating cell proliferation, migration, and differentiation, and aberrant EGFR signaling is implicated in a variety of cancers. EGFR signaling is triggered by extracellular ligand binding, which promotes EGFR dimerization and activati...

Descripción completa

Detalles Bibliográficos
Autores principales: Arkhipov, Anton, Shan, Yibing, Kim, Eric T., Shaw, David E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109842/
https://www.ncbi.nlm.nih.gov/pubmed/25058506
http://dx.doi.org/10.1371/journal.pcbi.1003742

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109842/
https://www.ncbi.nlm.nih.gov/pubmed/25058506
http://dx.doi.org/10.1371/journal.pcbi.1003742

Ejemplares similares