Cargando…
Membrane Interaction of Bound Ligands Contributes to the Negative Binding Cooperativity of the EGF Receptor
The epidermal growth factor receptor (EGFR) plays a key role in regulating cell proliferation, migration, and differentiation, and aberrant EGFR signaling is implicated in a variety of cancers. EGFR signaling is triggered by extracellular ligand binding, which promotes EGFR dimerization and activati...
Autores principales: | Arkhipov, Anton, Shan, Yibing, Kim, Eric T., Shaw, David E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109842/ https://www.ncbi.nlm.nih.gov/pubmed/25058506 http://dx.doi.org/10.1371/journal.pcbi.1003742 |
Ejemplares similares
-
Activation of the EGF Receptor by Ligand Binding and Oncogenic Mutations: The “Rotation Model”
por: Purba, Endang R., et al.
Publicado: (2017) -
EGF receptor ligands: recent advances
por: Singh, Bhuminder, et al.
Publicado: (2016) -
Binding of single-mutant epidermal growth factor (EGF) ligands alters the stability of the EGF receptor dimer and promotes growth signaling
por: Pascarelli, Stefano, et al.
Publicado: (2021) -
Her2 activation mechanism reflects evolutionary preservation of asymmetric ectodomain dimers in the human EGFR family
por: Arkhipov, Anton, et al.
Publicado: (2013) -
A dynamically coupled allosteric network underlies binding cooperativity in Src kinase
por: Foda, Zachariah H., et al.
Publicado: (2015)