Novel Small Molecule XPO1/CRM1 Inhibitors Induce Nuclear Accumulation of TP53, Phosphorylated MAPK and Apoptosis in Human Melanoma Cells

XPO1/CRM1 is a key nuclear exporter protein that mediates translocation of numerous cellular regulatory proteins. We investigated whether XPO1 is a potential therapeutic target in melanoma using novel selective inhibitors of nuclear export (SINE). In vitro effects of SINE on cell growth and apoptosi...

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Detalles Bibliográficos
Autores principales: Yang, Jennifer, Bill, Matthew A., Young, Gregory S., La Perle, Krista, Landesman, Yosef, Shacham, Sharon, Kauffman, Michael, Senapedis, William, Kashyap, Trinayan, Saint-Martin, Jean-Richard, Kendra, Kari, Lesinski, Gregory B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109950/
https://www.ncbi.nlm.nih.gov/pubmed/25057921
http://dx.doi.org/10.1371/journal.pone.0102983

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4109950/
https://www.ncbi.nlm.nih.gov/pubmed/25057921
http://dx.doi.org/10.1371/journal.pone.0102983

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