Crystal Structure of the Stress-Inducible Human Heat Shock Protein 70 Substrate-Binding Domain in Complex with Peptide Substrate

The HSP70 family of molecular chaperones function to maintain protein quality control and homeostasis. The major stress-induced form, HSP70 (also called HSP72 or HSPA1A) is considered an important anti-cancer drug target because it is constitutively overexpressed in a number of human cancers and pro...

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Detalles Bibliográficos
Autores principales: Zhang, Pingfeng, Leu, Julia I-Ju, Murphy, Maureen E., George, Donna L., Marmorstein, Ronen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110032/
https://www.ncbi.nlm.nih.gov/pubmed/25058147
http://dx.doi.org/10.1371/journal.pone.0103518

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110032/
https://www.ncbi.nlm.nih.gov/pubmed/25058147
http://dx.doi.org/10.1371/journal.pone.0103518

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