Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization

Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with exceptional potency. Remarkably, HIV-1 containing mutations that reportedly knockout 10E8 binding to linear MPER peptides are partially neutralize...

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Detalles Bibliográficos
Autores principales: Kim, Arthur S., Leaman, Daniel P., Zwick, Michael B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110039/
https://www.ncbi.nlm.nih.gov/pubmed/25058619
http://dx.doi.org/10.1371/journal.ppat.1004271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110039/
https://www.ncbi.nlm.nih.gov/pubmed/25058619
http://dx.doi.org/10.1371/journal.ppat.1004271

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