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Antibody to gp41 MPER Alters Functional Properties of HIV-1 Env without Complete Neutralization

Human antibody 10E8 targets the conserved membrane proximal external region (MPER) of envelope glycoprotein (Env) subunit gp41 and neutralizes HIV-1 with exceptional potency. Remarkably, HIV-1 containing mutations that reportedly knockout 10E8 binding to linear MPER peptides are partially neutralize...

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Detalles Bibliográficos
Autores principales:	Kim, Arthur S., Leaman, Daniel P., Zwick, Michael B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110039/ https://www.ncbi.nlm.nih.gov/pubmed/25058619 http://dx.doi.org/10.1371/journal.ppat.1004271

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