Association between the number of coadministered P-glycoprotein inhibitors and serum digoxin levels in patients on therapeutic drug monitoring

BACKGROUND: The ABC transporter P-glycoprotein (P-gp) is recognized as a site for drug-drug interactions and provides a mechanistic explanation for clinically relevant pharmacokinetic interactions with digoxin. The question of whether several P-gp inhibitors may have additive effects has not yet bee...

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Detalles Bibliográficos
Autores principales: Englund, Gunilla, Hallberg, Pär, Artursson, Per, Michaëlsson, Karl, Melhus, Håkan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411066/
https://www.ncbi.nlm.nih.gov/pubmed/15061868
http://dx.doi.org/10.1186/1741-7015-2-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC411066/
https://www.ncbi.nlm.nih.gov/pubmed/15061868
http://dx.doi.org/10.1186/1741-7015-2-8

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