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Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer

Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies...

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Autores principales: Raval, Mihir, Bande, Dinesh, Pillai, Anil K., Blaszkowsky, Lawrence S., Ganguli, Suvranu, Beg, Muhammad S., Kalva, Sanjeeva P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110696/
https://www.ncbi.nlm.nih.gov/pubmed/25120951
http://dx.doi.org/10.3389/fonc.2014.00120
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author Raval, Mihir
Bande, Dinesh
Pillai, Anil K.
Blaszkowsky, Lawrence S.
Ganguli, Suvranu
Beg, Muhammad S.
Kalva, Sanjeeva P.
author_facet Raval, Mihir
Bande, Dinesh
Pillai, Anil K.
Blaszkowsky, Lawrence S.
Ganguli, Suvranu
Beg, Muhammad S.
Kalva, Sanjeeva P.
author_sort Raval, Mihir
collection PubMed
description Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes, and side effects of Y-90 microsphere therapy for metastatic CRC.
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spelling pubmed-41106962014-08-12 Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer Raval, Mihir Bande, Dinesh Pillai, Anil K. Blaszkowsky, Lawrence S. Ganguli, Suvranu Beg, Muhammad S. Kalva, Sanjeeva P. Front Oncol Oncology Liver metastases from colorectal cancer (CRC) result in substantial morbidity and mortality. The primary treatment is systemic chemotherapy, and in selected patients, surgical resection; however, for patients who are not surgical candidates and/or fail systemic chemotherapy, liver-directed therapies are increasingly being utilized. Yttrium-90 (Y-90) microsphere therapy, also known as selective internal radiation therapy (SIRT) or radioembolization, has proven to be effective in terms of extending time to progression of disease and also providing survival benefit. This review focuses on the use of Y-90 microsphere therapy in the treatment of liver metastases from CRC, including a comprehensive review of published clinical trials and prospective studies conducted thus far. We review the methodology, outcomes, and side effects of Y-90 microsphere therapy for metastatic CRC. Frontiers Media S.A. 2014-07-25 /pmc/articles/PMC4110696/ /pubmed/25120951 http://dx.doi.org/10.3389/fonc.2014.00120 Text en Copyright © 2014 Raval, Bande, Pillai, Blaszkowsky, Ganguli, Beg and Kalva. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Raval, Mihir
Bande, Dinesh
Pillai, Anil K.
Blaszkowsky, Lawrence S.
Ganguli, Suvranu
Beg, Muhammad S.
Kalva, Sanjeeva P.
Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
title Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
title_full Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
title_fullStr Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
title_full_unstemmed Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
title_short Yttrium-90 Radioembolization of Hepatic Metastases from Colorectal Cancer
title_sort yttrium-90 radioembolization of hepatic metastases from colorectal cancer
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110696/
https://www.ncbi.nlm.nih.gov/pubmed/25120951
http://dx.doi.org/10.3389/fonc.2014.00120
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