The metabolic checkpoint kinase mTOR is essential for interleukin-15 signaling during NK cell development and activation

Interleukin-15 (IL-15) controls both the homeostasis and the peripheral activation of Natural Killer (NK) cells. The molecular basis for this duality of action remains unknown. Here we report that the metabolic checkpoint kinase mTOR is activated and boosts bioenergetic metabolism upon NK cell expos...

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Detalles Bibliográficos
Autores principales: Marçais, Antoine, Cherfils-Vicini, Julien, Viant, Charlotte, Degouve, Sophie, Viel, Sébastien, Fenis, Aurore, Rabilloud, Jessica, Mayol, Katia, Tavares, Armelle, Bienvenu, Jacques, Gangloff, Yann-Gaël, Gilson, Eric, Vivier, Eric, Walzer, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110708/
https://www.ncbi.nlm.nih.gov/pubmed/24973821
http://dx.doi.org/10.1038/ni.2936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110708/
https://www.ncbi.nlm.nih.gov/pubmed/24973821
http://dx.doi.org/10.1038/ni.2936

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