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Structure prediction of polyglutamine disease proteins: comparison of methods

BACKGROUND: The expansion of polyglutamine (poly-Q) repeats in several unrelated proteins is associated with at least ten neurodegenerative diseases. The length of the poly-Q regions plays an important role in the progression of the diseases. The number of glutamines (Q) is inversely related to the...

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Detalles Bibliográficos
Autores principales: Wen, Jingran, Scoles, Daniel R, Facelli, Julio C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110737/
https://www.ncbi.nlm.nih.gov/pubmed/25080018
http://dx.doi.org/10.1186/1471-2105-15-S7-S11