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Wilms’ Tumor Blastemal Stem Cells Dedifferentiate to Propagate the Tumor Bulk
An open question remains in cancer stem cell (CSC) biology whether CSCs are by definition at the top of the differentiation hierarchy of the tumor. Wilms’ tumor (WT), composed of blastema and differentiated renal elements resembling the nephrogenic zone of the developing kidney, is a valuable model...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110791/ https://www.ncbi.nlm.nih.gov/pubmed/25068119 http://dx.doi.org/10.1016/j.stemcr.2014.05.013 |