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REST and Stress Resistance in Aging and Alzheimer’s Disease
Human neurons are functional over an entire lifetime, yet the mechanisms that preserve function and protect against neurodegeneration during aging are unknown. Here we show that induction of the repressor element 1-silencing transcription/neuron-restrictive silencer factor (REST/NRSF) is a universal...
Autores principales: | Lu, Tao, Aron, Liviu, Zullo, Joseph, Pan, Ying, Kim, Haeyoung, Chen, Yiwen, Yang, Tun-Hsiang, Kim, Hyun-Min, Drake, Derek, Liu, X. Shirley, Bennett, David A., Colaiácovo, Monica P., Yankner, Bruce A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4110979/ https://www.ncbi.nlm.nih.gov/pubmed/24670762 http://dx.doi.org/10.1038/nature13163 |
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