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Thermodynamic Mechanism for the Evasion of Antibody Neutralization in Flaviviruses

[Image: see text] Mutations in the epitopes of antigenic proteins can confer viral resistance to antibody-mediated neutralization. However, the fundamental properties that characterize epitope residues and how mutations affect antibody binding to alter virus susceptibility to neutralization remain l...

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Detalles Bibliográficos
Autores principales: Maillard, Rodrigo A., Liu, Tong, Beasley, David W. C., Barrett, Alan D. T., Hilser, Vincent J., Lee, J. Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111217/
https://www.ncbi.nlm.nih.gov/pubmed/24950171
http://dx.doi.org/10.1021/ja503318x