Brain-Penetrant, Orally Bioavailable Microtubule-Stabilizing Small Molecules Are Potential Candidate Therapeutics for Alzheimer’s Disease and Related Tauopathies

[Image: see text] Microtubule (MT) stabilizing drugs hold promise as potential treatments for Alzheimer’s disease (AD) and related tauopathies. However, thus far epothilone D has been the only brain-penetrant MT-stabilizer to be evaluated in tau transgenic mice and in AD patients. Furthermore, this...

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Detalles Bibliográficos
Autores principales: Lou, Kevin, Yao, Yuemang, Hoye, Adam T., James, Michael J., Cornec, Anne-Sophie, Hyde, Edward, Gay, Bryant, Lee, Virginia M.-Y., Trojanowski, John Q., Smith, Amos B., Brunden, Kurt R., Ballatore, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111403/
https://www.ncbi.nlm.nih.gov/pubmed/24992153
http://dx.doi.org/10.1021/jm5005623

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111403/
https://www.ncbi.nlm.nih.gov/pubmed/24992153
http://dx.doi.org/10.1021/jm5005623

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