Purifying Selection in Deeply Conserved Human Enhancers Is More Consistent than in Coding Sequences

Comparison of polymorphism at synonymous and non-synonymous sites in protein-coding DNA can provide evidence for selective constraint. Non-coding DNA that forms part of the regulatory landscape presents more of a challenge since there is not such a clear-cut distinction between sites under stronger...

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Detalles Bibliográficos
Autores principales: De Silva, Dilrini R., Nichols, Richard, Elgar, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111549/
https://www.ncbi.nlm.nih.gov/pubmed/25062004
http://dx.doi.org/10.1371/journal.pone.0103357

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111549/
https://www.ncbi.nlm.nih.gov/pubmed/25062004
http://dx.doi.org/10.1371/journal.pone.0103357

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