Cargando…
Purifying Selection in Deeply Conserved Human Enhancers Is More Consistent than in Coding Sequences
Comparison of polymorphism at synonymous and non-synonymous sites in protein-coding DNA can provide evidence for selective constraint. Non-coding DNA that forms part of the regulatory landscape presents more of a challenge since there is not such a clear-cut distinction between sites under stronger...
| Autores principales: | , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111549/ https://www.ncbi.nlm.nih.gov/pubmed/25062004 http://dx.doi.org/10.1371/journal.pone.0103357 |