Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

The two major intracellular protein degradation systems, the ubiquitin-proteasome system (UPS) and autophagy, work collaboratively in many biological processes including development, apoptosis, aging, and countering oxidative injuries. We report here that, in human retinal pigment epithelial cells (...

Descripción completa

Detalles Bibliográficos
Autores principales: Tang, Bingrong, Cai, Jingjing, Sun, Lin, Li, Yiping, Qu, Jia, Snider, Barbara Joy, Wu, Shengzhou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111584/
https://www.ncbi.nlm.nih.gov/pubmed/25062253
http://dx.doi.org/10.1371/journal.pone.0103364

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111584/
https://www.ncbi.nlm.nih.gov/pubmed/25062253
http://dx.doi.org/10.1371/journal.pone.0103364

Ejemplares similares