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Proteasome Inhibitors Activate Autophagy Involving Inhibition of PI3K-Akt-mTOR Pathway as an Anti-Oxidation Defense in Human RPE Cells

The two major intracellular protein degradation systems, the ubiquitin-proteasome system (UPS) and autophagy, work collaboratively in many biological processes including development, apoptosis, aging, and countering oxidative injuries. We report here that, in human retinal pigment epithelial cells (...

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Detalles Bibliográficos
Autores principales:	Tang, Bingrong, Cai, Jingjing, Sun, Lin, Li, Yiping, Qu, Jia, Snider, Barbara Joy, Wu, Shengzhou
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111584/ https://www.ncbi.nlm.nih.gov/pubmed/25062253 http://dx.doi.org/10.1371/journal.pone.0103364

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