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Inhibition of Endocannabinoid Metabolism by the Metabolites of Ibuprofen and Flurbiprofen
BACKGROUND: In addition to their effects upon prostaglandin synthesis, the non-steroidal anti-inflammatory drugs ibuprofen and flurbiprofen inhibit the metabolism of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide (AEA) by cyclooxygenase-2 (COX-2) and fatty acid amide hydrolase (FA...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111603/ https://www.ncbi.nlm.nih.gov/pubmed/25061885 http://dx.doi.org/10.1371/journal.pone.0103589 |