Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures

High-grade serous ovarian cancer (HG-SOC), a major histologic type of epithelial ovarian cancer (EOC), is a poorly-characterized, heterogeneous and lethal disease where somatic mutations of TP53 are common and inherited loss-of-function mutations in BRCA1/2 predispose to cancer in 9.5–13% of EOC pat...

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Detalles Bibliográficos
Autores principales: Ow, Ghim Siong, Ivshina, Anna V, Fuentes, Gloria, Kuznetsov, Vladimir A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111681/
https://www.ncbi.nlm.nih.gov/pubmed/24879340
http://dx.doi.org/10.4161/cc.29271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111681/
https://www.ncbi.nlm.nih.gov/pubmed/24879340
http://dx.doi.org/10.4161/cc.29271

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