Characterisation of the Clinical Pharmacokinetics of Actinomycin D and the Influence of ABCB1 Pharmacogenetic Variation on Actinomycin D Disposition in Children with Cancer

BACKGROUND AND OBJECTIVE: Despite its important role in cancer treatment, there is currently very limited available information concerning the clinical pharmacology of actinomycin D (Act D). The study was designed to characterise Act D pharmacokinetics and investigate the impact of pharmacogenetic v...

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Detalles Bibliográficos
Autores principales: Hill, Christopher R., Cole, Michael, Errington, Julie, Malik, Ghada, Boddy, Alan V., Veal, Gareth J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2014
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111883/
https://www.ncbi.nlm.nih.gov/pubmed/24968986
http://dx.doi.org/10.1007/s40262-014-0153-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111883/
https://www.ncbi.nlm.nih.gov/pubmed/24968986
http://dx.doi.org/10.1007/s40262-014-0153-2

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