Cargando…

Characterisation of the Clinical Pharmacokinetics of Actinomycin D and the Influence of ABCB1 Pharmacogenetic Variation on Actinomycin D Disposition in Children with Cancer

BACKGROUND AND OBJECTIVE: Despite its important role in cancer treatment, there is currently very limited available information concerning the clinical pharmacology of actinomycin D (Act D). The study was designed to characterise Act D pharmacokinetics and investigate the impact of pharmacogenetic v...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hill, Christopher R., Cole, Michael, Errington, Julie, Malik, Ghada, Boddy, Alan V., Veal, Gareth J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer International Publishing 2014
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4111883/ https://www.ncbi.nlm.nih.gov/pubmed/24968986 http://dx.doi.org/10.1007/s40262-014-0153-2

Ejemplares similares

Characterisation of the roles of ABCB1, ABCC1, ABCC2 and ABCG2 in the transport and pharmacokinetics of actinomycin D in vitro and in vivo
por: Hill, Christopher R., et al.
Publicado: (2013)

Development of a physiologically based pharmacokinetic model of actinomycin D in children with cancer
por: Walsh, Christopher, et al.
Publicado: (2016)

ON THE DIFFERENTIAL CYTOTOXICITY OF ACTINOMYCIN D
por: Sawicki, Stanley G., et al.
Publicado: (1971)

In vitro and in silico evaluations of actinomycin X(2)and actinomycin D as potent anti-tuberculosis agents
por: Qureshi, Kamal Ahmad, et al.
Publicado: (2023)

Cyclophosphamide pharmacokinetics and pharmacogenetics in children with B-cell non-Hodgkin's lymphoma
por: Veal, Gareth J., et al.
Publicado: (2016)

THE RADIOAUTOGRAPHIC DETECTION OF DNA WITH TRITIATED ACTINOMYCIN D
por: Camargo, E. Plessmann, et al.
Publicado: (1967)

ON THE RECOVERY OF TRANSCRIPTION AFTER INHIBITION BY ACTINOMYCIN D
por: Sawicki, Stanley G., et al.
Publicado: (1972)

Discovery of actinomycin L, a new member of the actinomycin family of antibiotics
por: Machushynets, Nataliia V., et al.
Publicado: (2022)

DNA DEPENDENCE OF PLASTID DIFFERENTIATION INHIBITION BY ACTINOMYCIN D
por: Pogo, Beatríz G. T., et al.
Publicado: (1964)

INTRANUCLEAR FIBRILLAR BODIES IN ACTINOMYCIN D-TREATED OOCYTES
por: Lane, Nancy J.
Publicado: (1969)

Genetic interrelations in the actinomycin biosynthetic gene clusters of Streptomyces antibioticus IMRU 3720 and Streptomyces chrysomallus ATCC11523, producers of actinomycin X and actinomycin C
por: Crnovčić, Ivana, et al.
Publicado: (2017)

Proceedings: Interaction of actinomycin D, radiation and yeast cell survival.
por: van Duyse, E., et al.
Publicado: (1975)

THE EFFECTS OF ACTINOMYCIN D ON THE ULTRASTRUCTURE OF THE NUCLEUS OF THE AMPHIBIAN EMBRYONIC CELL
por: Jones, K. W., et al.
Publicado: (1964)

THE DIFFERENTIAL EFFECT OF ACTINOMYCIN D IN NORMAL AND VIRUS-TRANSFORMED CELLS
por: Williams, J. G., et al.
Publicado: (1973)

DETECTION OF DNA BY TRITIATED ACTINOMYCIN D ON ULTRATHIN FROZEN SECTIONS
por: Bernier, Roch, et al.
Publicado: (1972)

Antisense artifacts in transcriptome microarray experiments are resolved by actinomycin D
por: Perocchi, Fabiana, et al.
Publicado: (2007)

MEIOSIS AND INHIBITION OF OVULATION IN MOUSE EGGS TREATED WITH ACTINOMYCIN D
por: Jagiello, Georgiana M.
Publicado: (1969)

THE DIFFERENTIAL SENSITIVITY OF CULTURED CHICK MESODERMAL CELLS TO ACTINOMYCIN D
por: Piper, J. A., et al.
Publicado: (1969)

AKT mediates actinomycin D-induced p53 expression
por: Chen, Chih-Shou, et al.
Publicado: (2014)

Effect of low doses of actinomycin D on neuroblastoma cell lines
por: Cortes, Constanza L., et al.
Publicado: (2016)

TRITIATED ACTINOMYCIN D AS A CYTOCHEMICAL LABEL FOR SMALL AMOUNTS OF DNA
por: Ebstein, Bonnie Sue
Publicado: (1967)

The Circadian Rhythm in Photosynthesis in Acetabularia in the Presence of Actinomycin D, Puromycin, and Chloramphenicol
por: Sweeney, Beatrice M., et al.
Publicado: (1967)

Production of actinomycin-D by the mutant of a new isolate of Streptomyces sindenensis
por: Praveen, Vandana, et al.
Publicado: (2008)

The modification of the renal carcinogenicity of dimethylnitrosamine by actinomycin D and a protein deficient diet.
por: Hilfrich, J., et al.
Publicado: (1975)

EFFECT OF ACTINOMYCIN D ON RNA SYNTHESIS AND ANTIBODY FORMATION IN THE ANAMNESTIC RESPONSE IN VITRO
por: Smiley, J. Donald, et al.
Publicado: (1964)

THE EFFECTS OF ACTINOMYCIN D ON PROTEIN SYNTHESIS AND BEATING IN CULTURED RAT HEART CELLS
por: McCarl, Richard L., et al.
Publicado: (1969)

CELL KILLING BY ACTINOMYCIN D IN RELATION TO THE GROWTH CYCLE OF CHINESE HAMSTER CELLS
por: Elkind, M. M., et al.
Publicado: (1969)

SOME BIOCHEMICAL PROPERTIES OF CHINESE HAMSTER CELLS SENSITIVE AND RESISTANT TO ACTINOMYCIN D
por: Peterson, Robert H. F., et al.
Publicado: (1974)

NUCLEOLI OF DIPLOID CELL STRAINS : Their Normal Ultrastructure and the Effects of Toyocamycin and Actinomycin D
por: Phillips, Stephanie G., et al.
Publicado: (1971)

Methotrexate and actinomycin D chemotherapy in a patient with porphyria: a case report
por: Mikami, Yukiko, et al.
Publicado: (2016)

Actinomycin D Induces Hepatocyte Cell Death and Upregulation of FADD/MORT1
por: Kim, Peter K.M., et al.
Publicado: (2001)

Study of interactions between actinomycin D and oligonucleotides by microchip electrophoresis and ESI-MS
por: Zhou, Xiaomian, et al.
Publicado: (2007)

Effect of actinomycin D on ovarian reserve in low-risk gestational trophoblastic neoplasia
por: Xue, Wei, et al.
Publicado: (2023)

Isolation, characterization, anti-MRSA evaluation, and in-silico multi-target anti-microbial validations of actinomycin X(2) and actinomycin D produced by novel Streptomyces smyrnaeus UKAQ_23
por: Qureshi, Kamal A., et al.
Publicado: (2021)

THE BINDING OF ACTINOMYCIN D-(3)H TO HETEROCHROMATIN AS STUDIED BY QUANTITATIVE HIGH RESOLUTION RADIOAUTOGRAPHY
por: Simard, René
Publicado: (1967)

LIGHT AND ELECTRON MICROSCOPIC RADIOAUTOGRAPHY OF HEPATIC CELL NUCLEOLI IN MICE TREATED WITH ACTINOMYCIN D
por: de Man, J. C. H., et al.
Publicado: (1967)

Force spectroscopy reveals the DNA structural dynamics that govern the slow binding of Actinomycin D
por: Paramanathan, Thayaparan, et al.
Publicado: (2012)

Tegafur Substitution for 5-Fu in Combination with Actinomycin D to Treat Gestational Trophoblastic Neoplasm
por: Peng, Mei, et al.
Publicado: (2015)

Melatonin improves development of early mouse embryos impaired by actinomycin-D and TNF-α
por: Niknafs, Behrooz, et al.
Publicado: (2014)

Actinomycin D downregulates Sox2 and improves survival in preclinical models of recurrent glioblastoma
por: Taylor, Jessica T, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_j2fi8rqfa4m6qm3esjggm6c6eg