Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

The membrane-anchored serine protease, matriptase, is consistently dysregulated in a range of human carcinomas, and high matriptase activity correlates with poor prognosis. Furthermore, matriptase is unique among tumor-associated proteases in that epithelial stem cell expression of the protease suff...

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Detalles Bibliográficos
Autores principales: Sales, Katiuchia Uzzun, Friis, Stine, Konkel, Joanne E., Godiksen, Sine, Hatakeyama, Marcia, Hansen, Karina K., Rogatto, Silvia Regina, Szabo, Roman, Vogel, Lotte K., Chen, Wanjun, Gutkind, J. Silvio, Bugge, Thomas H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112178/
https://www.ncbi.nlm.nih.gov/pubmed/24469043
http://dx.doi.org/10.1038/onc.2013.563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112178/
https://www.ncbi.nlm.nih.gov/pubmed/24469043
http://dx.doi.org/10.1038/onc.2013.563

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