Akt phosphorylates and activates HSF-1 independent of heat shock, leading to Slug overexpression and epithelial-mesenchymal transition (EMT) of HER2-overexpressing breast cancer cells

Epithelial-mesenchymal transition (EMT) is an essential step for tumor progression, although the mechanisms driving EMT are still not fully understood. In an effort to investigate these mechanisms, we observed that heregulin-mediated activation of HER2, or HER2 overexpression, resulted in EMT, which...

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Detalles Bibliográficos
Autores principales: Carpenter, Richard L., Paw, Ivy, Dewhirst, Mark W., Lo, Hui-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112182/
https://www.ncbi.nlm.nih.gov/pubmed/24469056
http://dx.doi.org/10.1038/onc.2013.582

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112182/
https://www.ncbi.nlm.nih.gov/pubmed/24469056
http://dx.doi.org/10.1038/onc.2013.582

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