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KSHV vCyclin Counters the Senescence/G1 Arrest Response Triggered by NF-κB Hyper-activation

Many oncogenic viruses activate NF-κB as a part of their replicative cycles. We have shown recently that persistent and potentially oncogenic activation of NF-κB by the human T-lymphotropic virus 1 (HTLV-1) oncoprotein Tax immediately triggers a host senescence response mediated by cyclin-dependent...

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Detalles Bibliográficos
Autores principales: Zhi, Huijun, Zahoor, Muhammad Atif, Druck Shudofsky, Abigail M., Giam, Chou-Zen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112183/
https://www.ncbi.nlm.nih.gov/pubmed/24469036
http://dx.doi.org/10.1038/onc.2013.567