p53 suppresses carcinoma progression by inhibiting mTOR pathway activation

Genetic alterations in human cancers and murine models indicate that Rb and p53 have critical tumor suppressive functions in retinoblastoma, a tumor of neural origin, and neuroendocrine tumors including small cell lung cancer and medullary thyroid cancer (MTC). Rb inactivation is the initiating lesi...

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Detalles Bibliográficos
Autores principales: Akeno, Nagako, Miller, Ashley L., Ma, Xiaolan, Wikenheiser-Brokamp, Kathryn A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112184/
https://www.ncbi.nlm.nih.gov/pubmed/24469052
http://dx.doi.org/10.1038/onc.2013.589

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112184/
https://www.ncbi.nlm.nih.gov/pubmed/24469052
http://dx.doi.org/10.1038/onc.2013.589

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