Head-to-head, randomised, crossover study of oral versus subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses ≥15 mg may be overcome with subcutaneous administration

OBJECTIVE: To compare the relative bioavailability, safety and tolerability of oral methotrexate (MTX) and subcutaneous (SC) MTX administered via an auto-injector (MTXAI) in patients with rheumatoid arthritis (RA). METHODS: In this randomised, multicenter, open-label, three-way crossover study, pati...

Descripción completa

Detalles Bibliográficos
Autores principales: Schiff, Michael H, Jaffe, Jonathan S, Freundlich, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Clinical and Epidemiological Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112421/
https://www.ncbi.nlm.nih.gov/pubmed/24728329
http://dx.doi.org/10.1136/annrheumdis-2014-205228

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112421/
https://www.ncbi.nlm.nih.gov/pubmed/24728329
http://dx.doi.org/10.1136/annrheumdis-2014-205228

Ejemplares similares