High risk of tobacco-related cancers in CDKN2A mutation-positive melanoma families

BACKGROUND: Germline mutations in the tumour suppressor gene CDKN2A occur in 5–20% of familial melanoma cases. A single founder mutation, p.Arg112dup, accounts for the majority of CDKN2A mutations in Swedish carriers. In a national program, carriers of p.Arg112dup mutation have been identified. The...

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Detalles Bibliográficos
Autores principales: Helgadottir, Hildur, Höiom, Veronica, Jönsson, Göran, Tuominen, Rainer, Ingvar, Christian, Borg, Åke, Olsson, Håkan, Hansson, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2014
Materias:
Cancer Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112445/
https://www.ncbi.nlm.nih.gov/pubmed/24935963
http://dx.doi.org/10.1136/jmedgenet-2014-102320

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112445/
https://www.ncbi.nlm.nih.gov/pubmed/24935963
http://dx.doi.org/10.1136/jmedgenet-2014-102320

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