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Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
BACKGROUND: Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. METHODS: Genetic association study in a well-defined cohort of 148 CH patients with...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112603/ https://www.ncbi.nlm.nih.gov/pubmed/25043824 http://dx.doi.org/10.1186/1129-2377-15-46 |
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author | Schürks, Markus Frahnow, Antje Diener, Hans-Christoph Kurth, Tobias Rosskopf, Dieter Grabe, Hans-Jörgen |
author_facet | Schürks, Markus Frahnow, Antje Diener, Hans-Christoph Kurth, Tobias Rosskopf, Dieter Grabe, Hans-Jörgen |
author_sort | Schürks, Markus |
collection | PubMed |
description | BACKGROUND: Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. METHODS: Genetic association study in a well-defined cohort of 148 CH patients with information on drug response to triptans. CH was diagnosed according to the criteria of the International Headache Society. Genotypes of the 43-bp insdel (rs4795541) and A > G (rs25531) polymorphisms in the 5-HTTLPR promoter region were detected by restriction fragment length polymorphism analysis. We used logistic regression analysis to investigate the association between bi-allelic and tri-allelic genotypes and triptan non-response with genotype models. RESULTS: Mean age at study entry among patients was 44.6 ± 10.5 years, 77.7% were men. The genotype distribution both for the bi-allelic and the tri-allelic polymorphism was in Hardy-Weinberg equilibrium. We did not find an association of the bi-allelic polymorphism with triptan non-response. While the effect estimates for the S variant of the tri-allelic polymorphisms suggested increased odds of triptan non-response in CH patients (multivariable-adjusted odds ratio [95% confidence interval]: L*L* genotype—reference; L*S* genotype—1.33 [0.53-3.32]; S*S* genotype—1.46 [0.54-3.98]), the results were not statistically significant. CONCLUSIONS: Data from our study do not indicate a role of bi-allelic and tri-allelic genotypes of the 5-HTTLPR polymorphism in triptan non-response in CH. |
format | Online Article Text |
id | pubmed-4112603 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Springer |
record_format | MEDLINE/PubMed |
spelling | pubmed-41126032014-08-05 Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache Schürks, Markus Frahnow, Antje Diener, Hans-Christoph Kurth, Tobias Rosskopf, Dieter Grabe, Hans-Jörgen J Headache Pain Research Article BACKGROUND: Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. METHODS: Genetic association study in a well-defined cohort of 148 CH patients with information on drug response to triptans. CH was diagnosed according to the criteria of the International Headache Society. Genotypes of the 43-bp insdel (rs4795541) and A > G (rs25531) polymorphisms in the 5-HTTLPR promoter region were detected by restriction fragment length polymorphism analysis. We used logistic regression analysis to investigate the association between bi-allelic and tri-allelic genotypes and triptan non-response with genotype models. RESULTS: Mean age at study entry among patients was 44.6 ± 10.5 years, 77.7% were men. The genotype distribution both for the bi-allelic and the tri-allelic polymorphism was in Hardy-Weinberg equilibrium. We did not find an association of the bi-allelic polymorphism with triptan non-response. While the effect estimates for the S variant of the tri-allelic polymorphisms suggested increased odds of triptan non-response in CH patients (multivariable-adjusted odds ratio [95% confidence interval]: L*L* genotype—reference; L*S* genotype—1.33 [0.53-3.32]; S*S* genotype—1.46 [0.54-3.98]), the results were not statistically significant. CONCLUSIONS: Data from our study do not indicate a role of bi-allelic and tri-allelic genotypes of the 5-HTTLPR polymorphism in triptan non-response in CH. Springer 2014 2014-07-21 /pmc/articles/PMC4112603/ /pubmed/25043824 http://dx.doi.org/10.1186/1129-2377-15-46 Text en Copyright © 2014 Schürks et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. |
spellingShingle | Research Article Schürks, Markus Frahnow, Antje Diener, Hans-Christoph Kurth, Tobias Rosskopf, Dieter Grabe, Hans-Jörgen Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache |
title | Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache |
title_full | Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache |
title_fullStr | Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache |
title_full_unstemmed | Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache |
title_short | Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache |
title_sort | bi-allelic and tri-allelic 5-httlpr polymorphisms and triptan non-response in cluster headache |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112603/ https://www.ncbi.nlm.nih.gov/pubmed/25043824 http://dx.doi.org/10.1186/1129-2377-15-46 |
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