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Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache

BACKGROUND: Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. METHODS: Genetic association study in a well-defined cohort of 148 CH patients with...

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Autores principales: Schürks, Markus, Frahnow, Antje, Diener, Hans-Christoph, Kurth, Tobias, Rosskopf, Dieter, Grabe, Hans-Jörgen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112603/
https://www.ncbi.nlm.nih.gov/pubmed/25043824
http://dx.doi.org/10.1186/1129-2377-15-46
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author Schürks, Markus
Frahnow, Antje
Diener, Hans-Christoph
Kurth, Tobias
Rosskopf, Dieter
Grabe, Hans-Jörgen
author_facet Schürks, Markus
Frahnow, Antje
Diener, Hans-Christoph
Kurth, Tobias
Rosskopf, Dieter
Grabe, Hans-Jörgen
author_sort Schürks, Markus
collection PubMed
description BACKGROUND: Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. METHODS: Genetic association study in a well-defined cohort of 148 CH patients with information on drug response to triptans. CH was diagnosed according to the criteria of the International Headache Society. Genotypes of the 43-bp insdel (rs4795541) and A > G (rs25531) polymorphisms in the 5-HTTLPR promoter region were detected by restriction fragment length polymorphism analysis. We used logistic regression analysis to investigate the association between bi-allelic and tri-allelic genotypes and triptan non-response with genotype models. RESULTS: Mean age at study entry among patients was 44.6 ± 10.5 years, 77.7% were men. The genotype distribution both for the bi-allelic and the tri-allelic polymorphism was in Hardy-Weinberg equilibrium. We did not find an association of the bi-allelic polymorphism with triptan non-response. While the effect estimates for the S variant of the tri-allelic polymorphisms suggested increased odds of triptan non-response in CH patients (multivariable-adjusted odds ratio [95% confidence interval]: L*L* genotype—reference; L*S* genotype—1.33 [0.53-3.32]; S*S* genotype—1.46 [0.54-3.98]), the results were not statistically significant. CONCLUSIONS: Data from our study do not indicate a role of bi-allelic and tri-allelic genotypes of the 5-HTTLPR polymorphism in triptan non-response in CH.
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spelling pubmed-41126032014-08-05 Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache Schürks, Markus Frahnow, Antje Diener, Hans-Christoph Kurth, Tobias Rosskopf, Dieter Grabe, Hans-Jörgen J Headache Pain Research Article BACKGROUND: Triptans are only effective in terminating cluster headache (CH) attacks in 70-80% of patients. Pharmacogenetic aspects of the serotonin metabolism, specifically variation in the 5-HTTLPR may be involved. METHODS: Genetic association study in a well-defined cohort of 148 CH patients with information on drug response to triptans. CH was diagnosed according to the criteria of the International Headache Society. Genotypes of the 43-bp insdel (rs4795541) and A > G (rs25531) polymorphisms in the 5-HTTLPR promoter region were detected by restriction fragment length polymorphism analysis. We used logistic regression analysis to investigate the association between bi-allelic and tri-allelic genotypes and triptan non-response with genotype models. RESULTS: Mean age at study entry among patients was 44.6 ± 10.5 years, 77.7% were men. The genotype distribution both for the bi-allelic and the tri-allelic polymorphism was in Hardy-Weinberg equilibrium. We did not find an association of the bi-allelic polymorphism with triptan non-response. While the effect estimates for the S variant of the tri-allelic polymorphisms suggested increased odds of triptan non-response in CH patients (multivariable-adjusted odds ratio [95% confidence interval]: L*L* genotype—reference; L*S* genotype—1.33 [0.53-3.32]; S*S* genotype—1.46 [0.54-3.98]), the results were not statistically significant. CONCLUSIONS: Data from our study do not indicate a role of bi-allelic and tri-allelic genotypes of the 5-HTTLPR polymorphism in triptan non-response in CH. Springer 2014 2014-07-21 /pmc/articles/PMC4112603/ /pubmed/25043824 http://dx.doi.org/10.1186/1129-2377-15-46 Text en Copyright © 2014 Schürks et al.; licensee Springer. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited.
spellingShingle Research Article
Schürks, Markus
Frahnow, Antje
Diener, Hans-Christoph
Kurth, Tobias
Rosskopf, Dieter
Grabe, Hans-Jörgen
Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
title Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
title_full Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
title_fullStr Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
title_full_unstemmed Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
title_short Bi-allelic and tri-allelic 5-HTTLPR polymorphisms and triptan non-response in cluster headache
title_sort bi-allelic and tri-allelic 5-httlpr polymorphisms and triptan non-response in cluster headache
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112603/
https://www.ncbi.nlm.nih.gov/pubmed/25043824
http://dx.doi.org/10.1186/1129-2377-15-46
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