Cargando…

Mutations within the conserved NS1 nuclear export signal lead to inhibition of influenza A virus replication

BACKGROUND: The influenza A virus NS1 protein is a virulence factor and an antagonist of host cell innate immune responses. During virus infection NS1 protein has several functions both in the nucleus and in the cytoplasm and its intracellular localization is regulated by one or two nuclear localiza...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tynell, Janne, Melén, Krister, Julkunen, Ilkka
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112715/ https://www.ncbi.nlm.nih.gov/pubmed/25023993 http://dx.doi.org/10.1186/1743-422X-11-128

Ejemplares similares

Influenza A H3N2 subtype virus NS1 protein targets into the nucleus and binds primarily via its C-terminal NLS2/NoLS to nucleolin and fibrillarin
por: Melén, Krister, et al.
Publicado: (2012)

Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection
por: Sillanpää, Maarit, et al.
Publicado: (2009)

Hepatitis C virus NS2 and NS3/4A proteins are potent inhibitors of host cell cytokine/chemokine gene expression
por: Kaukinen, Pasi, et al.
Publicado: (2006)

Novel Avian Influenza A (H7N9) Virus Induces Impaired Interferon Responses in Human Dendritic Cells
por: Arilahti, Veera, et al.
Publicado: (2014)

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein
por: Ylösmäki, Leena, et al.
Publicado: (2016)

Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon
por: Lundberg, Rickard, et al.
Publicado: (2019)

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells
por: Jiang, Miao, et al.
Publicado: (2021)

No Serological Evidence of Influenza A H1N1pdm09 Virus Infection as a Contributing Factor in Childhood Narcolepsy after Pandemrix Vaccination Campaign in Finland
por: Melén, Krister, et al.
Publicado: (2013)

Features of Nuclear Export Signals of NS2 Protein of Influenza D Virus
por: Zhao, Lingcai, et al.
Publicado: (2020)

Middle East respiratory syndrome coronavirus (MERS-CoV) shows poor replication and weak induction of antiviral responses in human monocyte-derived macrophages and dendritic cells
por: Tynell, J., et al.
Publicado: (2015)

Maximal interferon induction by influenza lacking NS1 is infrequent owing to requirements for replication and export
por: Vicary, Alison C., et al.
Publicado: (2023)

Structural Basis for Influenza Virus NS1 Protein Block of mRNA Nuclear Export
por: Zhang, Ke, et al.
Publicado: (2019)

Nuclear export of the influenza virus ribonucleoprotein complex: Interaction of Hsc70 with viral proteins M1 and NS2
por: Watanabe, Ken, et al.
Publicado: (2014)

CHD3 facilitates vRNP nuclear export by interacting with NES1 of influenza A virus NS2
por: Hu, Yong, et al.
Publicado: (2014)

Asian and African lineage Zika viruses show differential replication and innate immune responses in human dendritic cells and macrophages
por: Österlund, Pamela, et al.
Publicado: (2019)

Full-Genome Sequences of Influenza A(H1N1)pdm09 Viruses Isolated from Finnish Patients from 2009 to 2013
por: Lakspere, Triin, et al.
Publicado: (2014)

Influenza A Virus NS1 Protein Promotes Efficient Nuclear Export of Unspliced Viral M1 mRNA
por: Pereira, Carina F., et al.
Publicado: (2017)

A nuclear export signal within the structural Gag protein is required for prototype foamy virus replication
por: Renault, Noémie, et al.
Publicado: (2011)

4-Octyl itaconate reduces influenza A replication by targeting the nuclear export protein CRM1
por: Ribó-Molina, Pau, et al.
Publicado: (2023)

Chenodeoxycholic Acid from Bile Inhibits Influenza A Virus Replication via Blocking Nuclear Export of Viral Ribonucleoprotein Complexes
por: Luo, Ling, et al.
Publicado: (2018)

Mutation of a Conserved Nuclear Export Sequence in Chikungunya Virus Capsid Protein Disrupts Host Cell Nuclear Import
por: Jacobs, Susan C., et al.
Publicado: (2017)

Blood MxA protein as a marker for respiratory virus infections in young children
por: Toivonen, Laura, et al.
Publicado: (2015)

Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development
por: Chutiwitoonchai, Nopporn, et al.
Publicado: (2017)

Comparative Analysis of Seven Viral Nuclear Export Signals (NESs) Reveals the Crucial Role of Nuclear Export Mediated by the Third NES Consensus Sequence of Nucleoprotein (NP) in Influenza A Virus Replication
por: Chutiwitoonchai, Nopporn, et al.
Publicado: (2014)

A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication
por: Isken, Olaf, et al.
Publicado: (2015)

Chemical intervention of influenza virus mRNA nuclear export
por: Esparza, Matthew, et al.
Publicado: (2020)

Correction: A Conserved NS3 Surface Patch Orchestrates NS2 Protease Stimulation, NS5A Hyperphosphorylation and HCV Genome Replication
por: Isken, Olaf, et al.
Publicado: (2016)

Filovirus VP24 Proteins Differentially Regulate RIG-I and MDA5-Dependent Type I and III Interferon Promoter Activation
por: He, Felix B., et al.
Publicado: (2022)

No evidence of autoimmunity to human OX(1) or OX(2) orexin receptors in Pandemrix-vaccinated narcoleptic children
por: Melén, Krister, et al.
Publicado: (2020)

Emerging Roles for the Influenza A Virus Nuclear Export Protein (NEP)
por: Paterson, Duncan, et al.
Publicado: (2012)

Reversible disruption of XPO1-mediated nuclear export inhibits respiratory syncytial virus (RSV) replication
por: Mathew, Cynthia, et al.
Publicado: (2021)

Altered RNA processing and export lead to retention of mRNAs near transcription sites and nuclear pore complexes or within the nucleolus
por: Paul, Biplab, et al.
Publicado: (2016)

Host Factor Nucleoporin 93 Is Involved in the Nuclear Export of Influenza Virus RNA
por: Furusawa, Yuri, et al.
Publicado: (2018)

Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence
por: Dankar, Samar K, et al.
Publicado: (2011)

Acetylation at K108 of the NS1 protein is important for the replication and virulence of influenza virus
por: Ma, Jingjiao, et al.
Publicado: (2020)

Replication-Competent ΔNS1 Influenza A Viruses Expressing Reporter Genes
por: Nogales, Aitor, et al.
Publicado: (2021)

Nuclear Export Inhibition for Pancreatic Cancer Therapy
por: Muqbil, Irfana, et al.
Publicado: (2018)

A length-dependent evolutionarily conserved pathway controls nuclear export of circular RNAs
por: Huang, Chuan, et al.
Publicado: (2018)

Size matters: conserved proteins function in length-dependent nuclear export of circular RNAs
por: Wan, Yao, et al.
Publicado: (2018)

Tpr is localized within the nuclear basket of the pore complex and has a role in nuclear protein export
por: Frosst, Phyllis, et al.
Publicado: (2002)

Cannot write session to /tmp/vufind_sessions/sess_5lrmffk9npqlnql671c4ci3td5