Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

BACKGROUND: The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is crucial for lymphocyte activation through signaling to the transcription factor NF-κB. Besides functioning as a scaffold signaling protein, MALT1 also acts as a cysteine protease that specifical...

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Detalles Bibliográficos
Autores principales: Mc Guire, Conor, Elton, Lynn, Wieghofer, Peter, Staal, Jens, Voet, Sofie, Demeyer, Annelies, Nagel, Daniel, Krappmann, Daniel, Prinz, Marco, Beyaert, Rudi, van Loo, Geert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112826/
https://www.ncbi.nlm.nih.gov/pubmed/25043939
http://dx.doi.org/10.1186/1742-2094-11-124

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112826/
https://www.ncbi.nlm.nih.gov/pubmed/25043939
http://dx.doi.org/10.1186/1742-2094-11-124

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