Cargando…

Pharmacological inhibition of MALT1 protease activity protects mice in a mouse model of multiple sclerosis

BACKGROUND: The paracaspase mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1) is crucial for lymphocyte activation through signaling to the transcription factor NF-κB. Besides functioning as a scaffold signaling protein, MALT1 also acts as a cysteine protease that specifical...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mc Guire, Conor, Elton, Lynn, Wieghofer, Peter, Staal, Jens, Voet, Sofie, Demeyer, Annelies, Nagel, Daniel, Krappmann, Daniel, Prinz, Marco, Beyaert, Rudi, van Loo, Geert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4112826/ https://www.ncbi.nlm.nih.gov/pubmed/25043939 http://dx.doi.org/10.1186/1742-2094-11-124

Ejemplares similares

MALT1 Proteolytic Activity Suppresses Autoimmunity in a T Cell Intrinsic Manner
por: Demeyer, Annelies, et al.
Publicado: (2019)

Long-Term MALT1 Inhibition in Adult Mice Without Severe Systemic Autoimmunity
por: Demeyer, Annelies, et al.
Publicado: (2020)

MALT1-Deficient Mice Develop Atopic-Like Dermatitis Upon Aging
por: Demeyer, Annelies, et al.
Publicado: (2019)

Combining precision oncology and immunotherapy by targeting the MALT1 protease
por: Mempel, Thorsten R, et al.
Publicado: (2022)

Mepazine Inhibits RANK-Induced Osteoclastogenesis Independent of Its MALT1 Inhibitory Function
por: Meloni, Laura, et al.
Publicado: (2018)

Attacking MALT1 for ABC-DLBCL therapy
por: Krappmann, Daniel
Publicado: (2012)

TRAF6 controls T cell homeostasis by maintaining the equilibrium of MALT1 scaffolding and protease functions
por: O’Neill, Thomas J., et al.
Publicado: (2023)

Analysis of T cells in mouse lymphoid tissue and blood with flow cytometry
por: Skordos, Ioannis, et al.
Publicado: (2021)

Combinatorial BTK and MALT1 inhibition augments killing of CD79 mutant diffuse large B cell lymphoma
por: Nagel, Daniel, et al.
Publicado: (2015)

Negative regulation of NF-κB and its involvement in rheumatoid arthritis
por: van Loo, Geert, et al.
Publicado: (2011)

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells
por: Ferch, Uta, et al.
Publicado: (2009)

Inhibition of MALT1 protease activity is selectively toxic for activated B cell–like diffuse large B cell lymphoma cells
por: Ferch, Uta, et al.
Publicado: (2009)

Inflammation and NF-κB Signaling in Prostate Cancer: Mechanisms and Clinical Implications
por: Staal, Jens, et al.
Publicado: (2018)

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20
por: Drennan, Michael B., et al.
Publicado: (2016)

Pharmacological Inhibition of MALT1 Protease Leads to a Progressive IPEX-Like Pathology
por: Martin, Kea, et al.
Publicado: (2020)

Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis
por: Vereecke, Lars, et al.
Publicado: (2010)

MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain
por: Kip, E., et al.
Publicado: (2018)

Molecular architecture and regulation of BCL10-MALT1 filaments
por: Schlauderer, Florian, et al.
Publicado: (2018)

MALT1 protease activity in primary effusion lymphoma
por: Juilland, Mélanie, et al.
Publicado: (2017)

Ancient Origin of the CARD–Coiled Coil/Bcl10/MALT1-Like Paracaspase Signaling Complex Indicates Unknown Critical Functions
por: Staal, Jens, et al.
Publicado: (2018)

Importance of Validating Antibodies and Small Compound Inhibitors Using Genetic Knockout Studies—T Cell Receptor-Induced CYLD Phosphorylation by IKKε/TBK1 as a Case Study
por: Lork, Marie, et al.
Publicado: (2018)

Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1
por: Jones, Alisha N., et al.
Publicado: (2022)

Inflammasomes in neuroinflammatory and neurodegenerative diseases
por: Voet, Sofie, et al.
Publicado: (2019)

Abscisic Acid as Pathogen Effector and Immune Regulator
por: Lievens, Laurens, et al.
Publicado: (2017)

MALT1 Protease Activity Is Required for Innate and Adaptive Immune Responses
por: Yu, Jong W., et al.
Publicado: (2015)

AIP augments CARMA1-BCL10-MALT1 complex formation to facilitate NF-κB signaling upon T cell activation
por: Schimmack, Gisela, et al.
Publicado: (2014)

A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection
por: Maelfait, Jonathan, et al.
Publicado: (2016)

Proteolytic Activity of the Paracaspase MALT1 Is Involved in Epithelial Restitution and Mucosal Healing
por: Wittner, Leonie, et al.
Publicado: (2023)

Alternative splicing of MALT1 controls signalling and activation of CD4(+) T cells
por: Meininger, Isabel, et al.
Publicado: (2016)

Malting quality and preharvest sprouting traits are genetically correlated in spring malting barley
por: Rooney, Travis E., et al.
Publicado: (2023)

Human immune disorder associated with homozygous hypomorphic mutation affecting MALT1B splice variant
por: Kutukculer, Necil, et al.
Publicado: (2021)

Bcl10-controlled Malt1 paracaspase activity is key for the immune suppressive function of regulatory T cells
por: Rosenbaum, Marc, et al.
Publicado: (2019)

A CARD9 Founder Mutation Disrupts NF-κB Signaling by Inhibiting BCL10 and MALT1 Recruitment and Signalosome Formation
por: De Bruyne, Marieke, et al.
Publicado: (2018)

MALT report
por: Smith, Tim, et al.
Publicado: (2021)

Malt Extract
por: Ebert, Albert E.
Publicado: (1870)

Inhibition of Caspases Increases the Sensitivity of L929 Cells to Necrosis Mediated by Tumor Necrosis Factor
por: Vercammen, Dominique, et al.
Publicado: (1998)

A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
por: Maelfait, Jonathan, et al.
Publicado: (2012)

Correction: A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection
por: Maelfait, Jonathan, et al.
Publicado: (2012)

IκB kinase ɛ (IKKɛ): A therapeutic target in inflammation and cancer
por: Verhelst, Kelly, et al.
Publicado: (2013)

Unrestrained cleavage of Roquin-1 by MALT1 induces spontaneous T cell activation and the development of autoimmunity
por: Schmidt, Henrik, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_kir00d8sd6h2tgtofsu53ba09o