Insulin Inhibits Cardiac Contractility by Inducing a G(i)-Biased β(2)-Adrenergic Signaling in Hearts

Insulin and adrenergic stimulation are two divergent regulatory systems that may interact under certain pathophysiological circumstances. Here, we characterized a complex consisting of insulin receptor (IR) and β(2)-adrenergic receptor (β(2)AR) in the heart. The IR/β(2)AR complex undergoes dynamic d...

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Detalles Bibliográficos
Autores principales: Fu, Qin, Xu, Bing, Liu, Yongming, Parikh, Dippal, Li, Jing, Li, Ying, Zhang, Yuan, Riehle, Christian, Zhu, Yi, Rawlings, Tenley, Shi, Qian, Clark, Richard B., Chen, Xiongwen, Abel, E. Dale, Xiang, Yang K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2014
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113065/
https://www.ncbi.nlm.nih.gov/pubmed/24677713
http://dx.doi.org/10.2337/db13-1763

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113065/
https://www.ncbi.nlm.nih.gov/pubmed/24677713
http://dx.doi.org/10.2337/db13-1763

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