Genetic determinants of amidating enzyme activity and its relationship with metal cofactors in human serum

BACKGROUND: α-amidation is a final, essential step in the biosynthesis of about half of all peptide hormones and neurotransmitters. Peptidylglycine α-amidating monooxygenase (PAM), with enzymatic domains that utilize Cu and Zn, is the only enzyme that catalyzes this reaction. PAM activity is detecte...

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Detalles Bibliográficos
Autores principales: Gaier, Eric D, Kleppinger, Alison, Ralle, Martina, Covault, Jonathan, Mains, Richard E, Kenny, Anne M, Eipper, Betty A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113131/
https://www.ncbi.nlm.nih.gov/pubmed/25022877
http://dx.doi.org/10.1186/1472-6823-14-58

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113131/
https://www.ncbi.nlm.nih.gov/pubmed/25022877
http://dx.doi.org/10.1186/1472-6823-14-58

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