MDM2 polymorphism associated with the development of cervical lesions in women infected with Human papillomavirus and using of oral contraceptives

BACKGROUND: The MDM2 gene is the major negative regulator of p53, a tumor suppressor protein. Single nucleotide polymorphism in promoter region of MDM2 gene leads to increased expression resulting in higher levels of MDM2 protein. This event increases the attenuation of the p53 pathway. Polymorphism...

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Detalles Bibliográficos
Autores principales: Amaral, Carolina MM, Cetkovská, Katerina, Gurgel, Ana PAD, Cardoso, Marcus V, Chagas, Bárbara S, Paiva Júnior, Sérgio SL, de Lima, Rita de Cássia Pereira, Silva-Neto, Jacinto C, Silva, Luiz AF, Muniz, Maria TC, Balbino, Valdir Q, Freitas, Antonio C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113664/
https://www.ncbi.nlm.nih.gov/pubmed/25075210
http://dx.doi.org/10.1186/1750-9378-9-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113664/
https://www.ncbi.nlm.nih.gov/pubmed/25075210
http://dx.doi.org/10.1186/1750-9378-9-24

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