Binding Modes of Two Scorpion Toxins to the Voltage-Gated Potassium Channel Kv1.3 Revealed from Molecular Dynamics

Molecular dynamics (MD) simulations are used to examine the binding modes of two scorpion toxins, margatoxin (MgTx) and hongotoxin (HgTx), to the voltage gated K(+) channel, Kv1.3. Using steered MD simulations, we insert either Lys28 or Lys35 of the toxins into the selectivity filter of the channel....

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Detalles Bibliográficos
Autores principales: Chen, Rong, Chung, Shin-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113748/
https://www.ncbi.nlm.nih.gov/pubmed/25054783
http://dx.doi.org/10.3390/toxins6072149

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4113748/
https://www.ncbi.nlm.nih.gov/pubmed/25054783
http://dx.doi.org/10.3390/toxins6072149

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